Page Views: 121 Date Added: 07/22/2011 Last Updated: 09/27/2011 Expiry Date: 07/19/2021 Product/Service Details Resveratrol 98% Grape Skin Extract Type: Grape Skin Extract Form: Powder Part: Other Extraction Type: Solvent Extraction Packaging: Drum Place of Origin: China (Mainland) Grade: Food/pharm Brand Name: OHI Model Number: OHI-0011 Specifications Test Method: HPLC Resveratrol-Grape Skin Extract CAS No.: 501-36-0 Active Ingredient: Trans-Resveratrol Specification: 50% 98% 99% Test Method: HPLC Molecular formula: C14H12O3 Molecular weight: 228.24 CAS No.: 501-36-0 Melt Point: 253°C~257°C Solubility: Poor solubility in water, soluble in aether, chloroform, ethanol, acetic acid and acetone. Appearance: Fine crystal powder Color: White Specific Rotation [α]: -77.5° (c=0.2, EtOH) Molecular structure: What is resveratrol: Resveratrol (trans-3,5,4'-trihydroxystilbene), belongs to a class of polyphenolic compounds called stilbenes , found largely in the skins of red grapes and root of Polygonum cuspidatum Sieb. et Zucc ( Japanese knotweed), is a component of Ko-jo-kon, an oriental medicine used to treat diseases of the blood vessels, heart and live.. Resveratrol is a fat-soluble compound that occurs in a trans and a cis configuration (see figure 1). Both cis- and trans-resveratrol also occur as glucosides (bound to a glucose molecule). Resveratrol-3-O-beta-glucoside is also called piceid. Sources While present in other plants, such as eucalyptus, spruce, and lily, and in other foods such as mulberries and peanuts, resveratrol's most abundant natural sources are Vitis vinifera, labrusca, and muscadine grapes, Polygonum cuspidatum Sieb. Cardiovascular Effects Many studies suggest that consuming alcohol (especially red wine) may reduce the incidence of coronary heart disease (CHD). Several studies have demonstrated that resveratrol is an effective antioxidant. It inhibits lipid peroxidation of low-density lipoprotein (LDL), prevents the cytotoxicity of oxidized LDL, and protects cells against lipid peroxidation. It is thought that because it contains highly hydrophilic and lipophilic properties, it can provide more effective protection than other well-known antioxidants, such as vitamins C and E. On the other hand, it is less effective than the antioxidants quercetin and epicatechin found in red wine. Reduced platelet aggregation has also been demonstrated in studies on resveratrol, further contributing to its prevention of atherosclerosis. To date, most of the research on resveratrol's antioxidant and anti-platelet properties has been done in vitro (in an artificial environment using test-tube or tissue-culture preparations). Further studies in animals and humans are necessary to determine whether resveratrol supplementation makes sense. Cancer-Related Effects Resveratrol is being studied to see how it affects the initiation, promotion, and progression of cancer. With regard to tumor initiation, it has been shown to act as an antioxidant by inhibiting free radical formation, and as an anti-mutagen in rat models. Resveratrol appears to decrease tumor promotion activity by inhibiting cyclooxygenase-1 (COX-1), an enzyme that converts arachidonic acid to pro-inflammatory substances that stimulate tumor-cell growth . Studies related to progression have found that resveratrol induced human promyelocytic leukemia cell differentiation and inhibited ribonucleotide reductase, an enzyme needed for DNA synthesis in proliferating cells . One appealing characteristic of resveratrol's anti-cancer potential is its minimal toxicity to blood-forming cells . More studies using both cellular and animal models are needed before any such data would be applicable to human use. The similarity in structure between resveratrol and diethylstilbestrol (a synthetic estrogen) has prompted investigations into resveratrol's potential as a phytoestrogen (a plant compound that produces estrogen-like effects). However, these properties also stimulate the growth of human breast cancer cells . This finding seems contrary to its other anticancer activities, and is a cause for concern. The Natural Products Association was cited in an article regarding a new dietary supplement that contains resveratrol, a substance researchers believe may help protect human cells from diseases such as cancer and arthritis. Direct Antioxidant Activity In the test tube, resveratrol effectively scavenges (neutralizes) free radicals and other oxidants and inhibits low density lipoprotein (LDL) oxidation . However, there is little evidence that resveratrol is an important antioxidant in vivo . After oral consumption of resveratrol, circulating and intracellular levels of resveratrol in humans are likely to be much lower than that of other important antioxidants, such as vitamin C, vitamin E and glutathione. Moreover, the antioxidant activity of resveratrol metabolites, which comprise most of the circulating resveratrol, may be lower than that of resveratrol. Inhibition of Vascular Smooth Muscle Cell Proliferation The proliferation of vascular smooth muscle cells plays an important role in the progression of atherosclerosis . Resveratrol has been found to inhibit the proliferation of vascular smooth muscle cells in culture . Inhibition of Platelet Aggregation Platelet aggregation is one of the first steps in the formation of a blood clot that can occlude a coronary or cerebral artery, resulting in myocardial infarction or stroke. Resveratrol has been found to inhibit platelet aggregation in vitro. Safety & Adverse Effects Resveratrol is not known to be toxic or cause adverse effects in humans, but there have been few controlled clinical trials. In rats, daily oral administration of trans-resveratrol at doses up to 300 mg/kg of body weight for 4 weeks resulted in no apparent adverse effects . Contact:Sallycheng CRGANIC HERB INC www.organic-herb.com Tel:86-731-82739210 Fax:86-731-82739211 Mobile:86-15111035952(working 24 hours ) MSN:sallycheng0426@hotmail.com Skype:sallycheng104 Mail:sallycheng@organic-herb.com

Company Information (Organic Herb Inc)

Company Profile: Globe Supplier for Plant Extracts,Herbal & Botanical Extracts,Organic Herb,Mushroon Extract,Animal Extract from China-Organic Herb Inc. Organic Herb Inc. (OHI) has been dedicated to the research and development of innovative nutraceutical ingredients since 1993. Our commitment to science and quality control has earned OHI recognition within the industry as a trusted supplier of ingredients of the highest quality. OHI is the Developer, Manufacturer, Exporter and Primary Supplier of the most remarkable alternative and complementary herbal health products and raw material available today. OHI develops and manufactures superior nutraceutical ingredients. OHI has advanced in-home lab as well as professional R&D people swift response to any of your request. We also co-operates with the world's most prestigious universities and private research institutions in the biological assessment of safety and effectiveness up to clinical phase II. We offer science-based ingredients, unconditional customer guarantee as well as excellent technical support, most of our products are tested by USA independent labs. We have very good relationship with famous USA independent Labs, and we are also member of NNFA (USA) as well as APHA. We have our own FDA registered Number. OHI’s major standardizedGreen Tea Extract, EGCG, Ginkgo Biloba Extract ,Luo Han Guo Extract 80% Mogrosides 25% Mogrosides, Black Sesame Extract 90% Sesamin, Flaxseed Extract 25% Lignans SDG Secoisolariciresinol Diglycoside, Honeysuckle Flower Extract 99% Chlorogenic acid, 5-HTP, Resveratrol 99%, Ginseng Root Extract 80% Ginsenosides, Grape Seed Extract 95% OPC, Soy Bean Extract 40% Isoflavones, Huperzine A 99%, Tanshinone II A 80%, Synephrine 90%, Puerarin 97%, Rhodiola Rosea Extract, Pueratiae Root Extract, Echinacea Extract, Bitter Melon Extract, Citrus Aurantium Extract, Cordyceps Extract, Epimedium Extract, Red Clover Extract, Apple Bark Extract 40% phloretin, Galanthamine, Banaba Extract 1% Corosolic Acid, Loquat Leaf Extract 25% ursolic acid, Bilberry Extract 25% Anthocyanidins, Black Tea Extract 40% Theaflavines, Garlic Extract (freeze Dried), Macleaya cordata Extract, Piper Nigrum Extract 90% piperine, Lycopene, Yohimbine, Artemisinin, Shikimic acid,Eurycoma longifolia Extract and so on ..... are well sale more than 30 countries throughout the world.. >> More Website URL: http://www.bridgat.com/u41138