Page Views: 273 Date Added: 05/20/2010 Last Updated: 05/20/2010 Expiry Date: 05/15/2029 Product/Service Details Common name: difenoconazole IUPAC name: cis,trans-3-chloro-4-[4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-2-yl]phenyl 4-chlorophenyl ether Chemical Abstracts name: 1-[2-[4-(4-chlorophenoxy)-2-chlorophenyl]-4-methyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole CAS RN: [119446-68-3] unstated stereochemistry PHYSICAL CHEMISTRY Composition: Ratio of cis- to trans- isomers is in the range 0.7 to 1.5. Mol. wt.: 406.3; M.f.: C19H17Cl2N3O3; Form: White to light beige crystals. M.p.: 78.6 ºC; V.p. 3.3x10-5 mPa (25 ºC). KOW: logP = 4.20 (25 ºC). Henry: 1.5x10-6 Pa m3 mol-1 (calc.) S.g./density: 1.40 (20 ºC). Solubility: In water 15 mg/l (25 ºC). In ethanol 330, acetone 610, toluene 490, n-hexane 3.4, n-octanol 95 (all in g/l, 25 ºC). Stability: Stable up to 150 ºC. Hydrolytically stable. APPLICATIONS Biochemistry: Sterol demethylation inhibitor. Inhibits cell membrane ergosterol biosynthesis, stopping development of the fungus. Mode of action: Systemic fungicide with preventive and curative action. Absorbed by the leaves, with acropetal and strong translaminar translocation. Uses: Systemic fungicide with a novel broad-range activity protecting the yield and crop quality by foliar application or seed treatment. Provides long-lasting preventive and curative activity against Ascomycetes, Basidiomycetes and Deuteromycete,s including Alternaria, Ascochyta, Cercospora, Cercosporidium, Colletotrichum, Guignardia, Mycosphaerella, Phoma, Ramularia, Rhizoctonia, Septoria, Uncinula, Venturia spp., Erysiphaceae, Uredinales and several seed-borne pathogens. Used against disease complexes in grapes, pome fruit, stone fruit, potatoes, sugar beet, oilseed rape, banana, cereals, rice, soya beans, ornamentals and various vegetable crops, at 30-125 g/ha. Used as a seed treatment against a range of pathogens in wheat and barley, at 3-24 g/100 kg seed. Phytotoxicity: In wheat, early foliar applications at growth stages 29-42 might cause, in certain circumstances, chlorotic spotting of leaves, but this has no effect on yield. Formulation types: DS; EC; FS; SC; WG. MAMMALIAN TOXICOLOGY Oral: Acute oral LD50 for rats 1453, mice >2000 mg/kg. Skin and eye: Acute percutaneous LD50 for rabbits >2010 mg/kg. Non-irritant to eyes and skin (rabbits). Non-sensitising to skin (guinea pigs). Inhalation: LC50 (4 h) for rats 3300 mg/m3 air. NOEL: (2 y) for rats 1.0 mg/kg b.w. daily; (1.5 y) for mice 4.7 mg/kg b.w. daily; (1 y) for dogs 3.4 mg/kg b.w. daily. ADI: 0.01 mg/kg b.w. Other: Not teratogenic or mutagenic. Toxicity class: WHO (a.i.) III EC hazard: (R22) ECOTOXICOLOGY Birds: LD50 (9-11 d) for mallard ducks >2150 mg/kg. LC50 for bobwhite quail >4760, mallard ducks >5000 ppm. Fish: LC50 (96 h) for rainbow trout 0.8, bluegill sunfish 1.2, sheepshead minnow 0.82 mg/l. Daphnia: LC50 (48 h) 0.77 mg/l. Algae: EC50 (72 h) for Scenedesmus subspicatus 1.2 mg/l. Other aquatic spp.: EC50 (96 h) for Eastern oysters 0.45 mg/l; (14 d) for Lemna gibba 18.5 mg/l. Bees: Non-toxic to honeybees; LD50 (oral) >187 ug/bee; LC50 (contact) >100 ug/bee. Worms: LC50 for earthworms >610 mg/kg. ENVIRONMENTAL FATE Animals: After oral administration, difenoconazole was rapidly eliminated practically to entirety, with urine and faeces. Residues in tissues were not significant and there was no evidence for accumulation. Plants: Two routes of metabolism: one by a triazole route to triazolylalanine and triazolylacetic acid; the other by hydroxylation of the phenyl ring followed by conjugation. Soil/Environment: Practically immobile in soil, strong adsorption to soil particles, low potential to leach below top soil layer. Soil dissipation rate is slow and dependent on application rate. DT50 for photolysis 145 d (natural sunlight).

Difenoconazole

Company Information (Shanghai Skyblue Chemical Co., Ltd.)

Company Profile: Shanghai Skyblue Chemical Co., Ltd. is an integrated company located in Pudong New Area of Shanghai China. Our business scopes include the development, manufacturing, researching, and marketing agrochemicals. We are capable of supplying a wide range of high quality agrochemicals, including insecticides (especially household and public health insecticides), fungicides, herbicides, pesticide synergists and other relative agrochemicals in both technical grade and formulation in different packages as per customer's requirements. To make quality products is our credo. We always target to provide our customers with top quality products along with moderate prices and professional services, and endeavor to be a 360o-solution supplier for agrochemicals. Currently our products are being exported to more than twenty countries and enjoy high reputation in the global market. On the basis of equality and mutual benefits, we always look forward to establishing and maintaining long term partnerships with all customers toward a future of resplendence. At present we can supply the following products: Insecticides: Acetamiprid,Alpha-Cypermethrin, Aluminium Phosphide, Azamethiphos, Beta-Cyfluthrin, Bifenthrin, Bioallethrin, Carbaryl, Carbofuran, Carbosulfan, Cartap, Chlorpyrifos, Cyfluthrin, D-Allethrin, D-Cyphenothrin, Deltamethrin, Dichlorvos, Diethyltoluamide, Dimehypo, Dimethoate, D-Phenothrin, D-Tetramethrin, Empenthrin, Es-bioallethrin, Es-Fenvalerate, Etofenprox, Fenitrothion, Fenpropathrin, Fenthion, Fenvalerate, Fipronil, Flumethrin, Hydramethylnon, Imidacloprid, Imiprothrin, Lambda-cyhalothrin, Malathion, Permethrin, Pirimiphos-methyl, Prallethrin, Propoxur, S-Bioallethrin, Tefluthrin, Tetramethrin, Thiocyclam, Transfluthrin Fungicides: Clofentezine, Difenoconazole, Mancozeb, Metiram, Propiconazole, Propineb, Tebuconazole, Thiabendazole Herbicides: Acetochlor, Ametryn, Atrazine, Bensulfuron-methyl, Butachlor, Chlorimuron-ethyl, Chlorsulfuron, Cyanazine, Fenchlorazole, Fenoxaprop-p-ethyl, Glyphosate, Metsulfuron-methyl, Nicosulfuron, Prometryn, Pyrazosulfuron-ethyl, Quinclorac, Quizalofop-p-ethyl, Simazine, Simetryn, Terbuthylazine, Terbutryn, Tribenuron-methyl Pesticide Synergists: Piperonyl Butoxide, MGK 264. >> More Website URL: http://www.bridgat.com/u15636